Donor egg (oocyte) treatment
The reason for using donated oocytes (DO) is, for example, premature ovarian failure, status post ovary removal, status post radiotherapy or chemotherapy, the risk of transmission of a genetic disorder to an offspring, recurrent spontaneous miscarriage, poor own oocytes and repeated IVF-ET failures.
Egg donation in the Czech Republic is allowed by law, but is strictly anonymous. Likewise, in the case of donor sperm, we can reveal only the non-identifying information about the donor, e.g. age, blood type, eye and hair colour, height, etc. Those are the characteristics that we can reveal.
Treatment using donor eggs is a more complicated and more expensive process than treatment using donor sperm because the donor undergoes the burden of hormonal stimulation and egg retrieval under general anaesthesia.
The oocyte (egg) is a large delicate cell located in the middle of division. In such a cell, there is a greater risk of damage due to freezing, and therefore we prefer to use "fresh" eggs.
During treatment we mostly synchronize menstrual cycles of the donor and recipient. The retrieved oocytes are immediately fertilized with sperm from the recipient’s partner. Resulting embryos are cultured and then transferred into the uterus of the recipient at the time when her endometrium is ideally prepared for embryo implantation. For the recipient, this means using the medication to synchronize the cycle (mostly contraception), and then oestrogens and progestogens (mostly in the form of tablets and vaginal capsules). In principle, the treatment resembles FET with HRT, but it is a "fresh" embryo that is being transferred.
Today, such freezing methods and media have been developed that even oocytes can be successfully freezed. We use this procedure when we do not have sperm for fertilization.
Oocyte donor must fulfill strict criteria, namely: perfect health and the age under 35; they also have to undergo genetic testing and screening for sexually transmitted diseases. Hormonal examination and the test of ovarian reserve must be carried out to make sure that the donated eggs have required quality. The donor receives financial compensation for costs associated with donation.
The success rate of treatment using donor oocytes is high, more than 50 % per embryotransfer.