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Dobrý den,
5 let se snažím otěhotnět. Mám PCOS, 3 trombofilní mutace (obě MTHFR a protrombin), na imunologickém vyšetření mi našli výrazně zvýšenou buněčnou imunitu proti spermiím a trofoblastu, po 3 měsících se srovnala skoro do normálu. Už se mi hodněkrát stalo, že jsem měla všechny příznaky těhotenství (zvětšená prsa, bolavé bradavky), slabě pozitivní test asi tak 2
dny před termínem MS, ale pak vždycky klesne bazální teplota a přijde menstruace. Mám dojem, že asi není problém s oplodněním, ale s uhnízděním embrya. Prosím poradíte mi, co byste mi doporučovali nebo čím to může
být? Nemohou to způsobovat ty trombofilní mutace? Nebo imunologie, beru stále Prednison 2,5 mg? Už jsem z toho všeho na dně. Jinak mám za sebou jedno neúspěšné IVF, hcg nejprve stouplo, ale pak kleslo, přišla MS a bylo po všem. Dále 3 neúspěšné pokusy IUI. Vážně už nevím, jak dál nebo kam se obrátit o pomoc. Předem velice děkuji za odpověď.

Odpověď na Vaše otázky není jednoduchá. Problematika trombofilních mutací a imunologických testů je velmi komplikovaná a i mezi odbornou veřejností nevládne bohužel zcela jednotný názor.
Ve Vašem případě se téměř určitě jedná o opakované časné těhotenské ztráty. Jejich příčin je celá řada a většinou je ani nedokážeme odhalit.
Souvislost s patolgickým nálezem v trombofilních mutacích být může, ale znám řadu žen, které s podobným nálezem otěhotněly a donosily.
Imunitní mechanismy zcela jistě hrají v otázce implantace embrya klíčovou roli. Současné vyšetřovací postupy jsou však podle mých zkušeností ne zcela vyhovující.
Spolupodílet na časné ztrátě se může i hormonální porucha ve smyslu nízkých hladin progesteronu a třeba i patologie v děložní dutině.
Co zkusit? Lze uvážit hormonální podporu druhé poloviny cyklu a počátku gravidity progesteronem (např. Utrogestan). Prednison určitě nemůže vadit, berte ho dále. Některé práce popisují dobrý efekt dlouhodobého užívání nízkých dávek Anopyrinu (rovněž nemůže škodit). Po stránce diagnostické bych doporučil doplnit hysteroskopické vyšetření, samozřejmě pokud již nebylo provedeno.
Především ale doporučuji obrnit se extrémní trpělivostí. Pokud jste opakovaně otěhotněla (i časná ztráta je těhotenství) je opravdu vysoká pravděpodobnost, že se Vám dříve či později podaří plod i donosit Vím, že se mi to lehce říká, ale opravdu tomu tak je. Možná Vás čeká ještě několik neúspěchů, opět budete prožívat radost ze zjištění těhotenství a trauma z jeho ztráty. Věřte ale v úspěch. Psychická pohoda je velmi velmi důležitá.
Přeji Vám vše nejlepší do nového roku, a především, aby vše dobře dopadlo co nejdříve.
MUDr. Jan Šulc

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ProCrea Swiss IVF Center s.r.o.
Nádražní Str. 762/32
(entrance from Rozkošného Str. 1058/3)
150 00  Prague 5 - Smíchov

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We help to bloossom new lives. We are an IVF clinic with an individual and sensitive approach.

13.01.2021

We help to bloossom new lives. We are an IVF clinic with an individual and sensitive approach. Reproductive medicine has made greate progress in recent years and can help with most reproductive problems. Even in the Czech Republic, the treatments have already helped thousands of couples with their families. The peak of a woman’s fertility is reached at around age 20 and after age 25 fertility slowly starts to decrease.  More rapid decrease happens normally after the age 35 when embryo implantation rates decreases and women face higher chances of having a miscarriages. The reason are explained by genetic abnormalities in eggs which result in genetically abnormal embryos without potential to develop into healthy pregnancy.  Men are not facing this challenges as they produce new, young sperm every 60-70 days and are not so limited by reproductive age.  Our grandmothers and mothers were more in line with this biologic factors, but today as young women deal with education, career, financial independence and are waiting to align with right partner, motherhood is postponed to late 20-ies, to be exact: 29 years old which is Czech and European average to become mothers for the first time mothers. Getting further away from biology, many couples turn to reproductive medicine to help them plan parenthood. Our job is not just to treat, but also to educate our patients when to seek help, we recommend to contact the clinic right away if: •    You are 35 or younger and you’ve been trying to get pregnant for 1 year without success •    You are over age 35 and you’ve been trying for more than 6 months without success •    You’re over age 40 and you’d like to start a family Time factor plays important role and we encourage woman to continue trying naturally but also to learn about their fertility and make realistic plan with time frame how to plan pregnancy. Contacting a clinic is not a taboo and many couples are parents today to children born with the help of assisted preproduction. Clinic has Info Center ready to answer all your questions and organize your first visit to the clinic ProCrea Swiss IVF Center in Prague.  Contacts:  Phone: +420 257 212 516 – 518 E-mail: info@procreaivf.cz  

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Happy New Year 2021

31.12.2020

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Christmas holidays non-working day

07.12.2020

We would like to inform you that our clinic will be closed 24th – 27th December. In case of any questions, please contact us ahead. We wish you Happy Holidays! ProCrea Swiss IVF Center Prague

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Your health and safety are our priorities

16.10.2020

Clinic is operating daily in accordance with epidemiology instructions in Czech Republic. Your health and safety are our priorities.   If you are travelling from abroad, we offer: - Official clinic invitation to confirm that travel is of medical purpose - FREE COVID PCR test for travel purposes for our female patients as part of their IVF treatment packages Feel free to contact us for more information.

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Annonymous spermiogram analysis

19.05.2020

The same as every year, this summer in June we offer “Annonymous spermiogram analysis”. You can book your sperm analysis using specific individual code according to which we wil track your result. The cost of the analysis is 1000 Kc.  Booking is possbile at the reception, by e-mail or phone.

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Easter opening hours

08.04.2020

Dear patients,  during Easter will be the clinic opened just for urgent cases on Saturday 11th and Monday 13th only in the morning. In urgency call +420 602  758 353. The clinic opens for you on Tuesday 14th April.  Thank you for understanding. We wish you happy Easter!

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Client ranking

The most beautiful Christmas

The most beautiful Christmas
05.01.2021

"We would like to thank you very much for our treasure Karolína. We are your clients and thanks to you, our little girl was born on December 20, 2020 and became our most beautiful Christmas gift. The little one was 48cm and 3210g and we are very grateful to you.” Family Ženatík

Beautiful

Beautiful "Thank you" from a happy, new mother
15.04.2020

Even during COVID pandemic time babies are born, including via IVF treatments. We received this beautiful thank you message from a happy new mother.

"I wish you primarily good health, so you could handle this challenging times and continue with your work. You have helped us greatly and we will be forever grateful."

Thank you

Thank you
04.03.2020

Dr. Šulc,

we would like to use this opportunity to thank you and your colleagues for the  care we received during our IVF treatment and following pregnancy from May 2019 until now.

We are especially grateful for your personal approach to our case, we felt cared after even when situation was not easy, we always knew we can turn to you for advice. We are aware that today it is unfortunatelly not a standard everywhere, so we value not only your medical help but also kind approach.

Michalka

Michalka
26.02.2020

Finaly even me can boast with joyfull news. On 10th February 2020 was born gorgeous girl Michalka (3650 g, 51 cm). She arrived 10 days after predicted date of birth. We, happy parents, want to thank to the whole Gest team for the longwished happiness. Markéta and Lukáš

Michal

Michal
07.01.2020

Finally can we show off our babyboy Michal. He was born on 24.12.2019, his weight was 2720g and was 48 cm long. Michal came into this world little bit earlier - at 37th week. 
Thanks a lot to the whole team - finally we have our little treasure. 
Happy parents Jaroslava and Luboš 

Zuzanka

Zuzanka
11.12.2019

We would like to thank the whole GEST team for the birth of our babygirl Zuzanka. She was born on 13. 7. 2018. Her weight was just 1120g - she was early born (28+6 week). She became a healthy, beautifull girl.
Grretings and thanks a lot again. 
Milena Wágnerová  

 

Address

ProCrea Swiss IVF Center s.r.o.
Nádražní Str. 762/32
(entrance from Rozkošného Str. 1058/3)
150 00 Praha 5 - Smíchov

Surgery hours:

Monday 8:00 - 16:30
Tuesday 8:00 - 19:00
Wednesday 8:00 - 19:00
Thursday 8:00 - 16:30
Friday 8:00 - 16:30
Saturday Emergency only

Contact

Phone.: +420 257 212 516 - 518
Mobile: +420 602 328 346
E-mail: info@procreaivf.cz  
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